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MOTS-c
MOTS-c is a mitochondrial-derived peptide (MDP) encoded within mitochondrial DNA. A novel exercise-mimetic that activates AMPK signaling and translocates to the nucleus under metabolic stress for adaptive gene regulation.
Available SKUs
| Model | Specification | MOQ |
|---|---|---|
| MS10 | 10mg / 10ml | 1 vial |
| MS40 | 40mg / 10ml | 1 vial |
Product Overview
MOTS-c is a mitochondrial-derived peptide (MDP) encoded within mitochondrial DNA. A novel exercise-mimetic that activates AMPK signaling and translocates to the nucleus under metabolic stress for adaptive gene regulation.
Research Applications
- First mitochondrial-derived peptide with metabolic activity
- Exercise-mimetic: activates AMPK via AICAR accumulation
- Nuclear translocation under metabolic stress (retrograde signaling)
- Endogenous circulating peptide — levels decline with age
- Published in Cell Metabolism (Lee et al., 2015)
Key Features
- Modulates folate cycle, glucose uptake, and fatty acid oxidation
- ≥99% purity confirmed by RP-HPLC and ESI-MS
- For laboratory research use only
| Catalog Number | MS |
|---|---|
| Sequence | MRWQEMGYIFYPRKLR |
| Origin | Mitochondrial 12S rRNA gene |
| Class | Mitochondrial-Derived Peptide (MDP) |
| Molecular Weight | ~2174.6 Da |
| Mechanism | Folate cycle → AICAR → AMPK activation |
| Form | Lyophilized powder |
| Purity | ≥99% (RP-HPLC) |
| Storage | -20°C, desiccated |
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